Jorvet bone marrow manual

killer19   16-Sep-2017 00:18   Комментариев к записи Jorvet bone marrow manual 6

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A method is described in which unmobilized, hy purified bone marrow stem cells are transduced with a minimum amount of self-inactivating (SIN) lentiviral vector containing a potent antisickling β-globin gene.

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These cells, which were transduced in the absence of cytokine stimulation, fully reconstitute irradiated recipients and correct the hemolytic anemia and organ pathology that characterize the disease in humans.

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Although sickle cell anemia was the first hereditary disease to be understood at the molecular level, there is still no adequate long-term treatment.

Cancer-associated IDH2 mutants drive an acute myeloid. -

Allogeneic bone marrow transplantation is the only available cure, but this procedure is limited to a minority of patients with an available, histocompatible donor.

Jorvet bone marrow manual:

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